Base editor technique in treating beta-Thalassemia in Human Embryo
A team of researchers from Sun Yat-sen University in Guangzhou, China, used what's called a base editor technique to change a single G back to an A in the DNA code of an embryonic cell's HBB gene. The change might have been tiny, but in its mutated form HBB can't produce the protein beta-globin needed to build the oxygen-carrying haemoglobin for our red blood cells. A shortage of haemoglobin means a shortage of oxygen, impeding growth and development and leading to a lifetime of blood transfusions to treat anaemia – if the embryo survives at all. Beta-thalassaemia is usually a recessive condition, meaning both parents need to contribute a copy of the mutated gene for anaemia to develop in their child. Correcting the mutations in this gene could help parents carry an embryo to term, or remove the trait from family lines. About 400 different kinds of code-corruptions can affect HBB.In this case, the researchers focussed on a single point-mutation that targ...